青蒿素生物合成分子机制及调控研究进展(10)
[64]Liu Y, Ye H C, Wang H, et al Molecular cloning, Escherichiacoli expression and genomic organization of squalene synthasegene from Artemisia annua[J]Acta Bot Sin,2003,45:608
[65]Zhang L, Jing F Y, Li F P, et al Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective antimalarial drug, by hairpinRNAmediated genesilencing[J] Biotechnol Appl Biochem,2009,52:199
[66]Cai Y, Jia J W, Crock J, et al AcDNA clone for βcaryophyllene synthase from Artemisia annua[J] Phytochemistry, 2002,61:523
[67]Chen J L, Fang H M, Ji Y P, et alArtemisinin biosynthesisenhancement in transgenic Artemisia annua plants by downregulation of the betacaryophyllene synthase gene[J] Planta Med, 2011,77:1759
[68]Han J, Wang H, Lundgren A, et al Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants[J] Phytochemistry, 2014, 102:89
[69]Ma D, Pu G, Lei C, et alIsolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha4,11diene synthase gene, a key gene of artemisinin biosynthesis[J] Plant Cell Physiol, 2009,50:2146
[70]Lu X, Jiang W, Zhang L, et al AaERF1 positively regulates the resistance to Botrytis cinerea in Artemisia annua[J] PLoS ONE, 2013, 8:e57657
[71]Lorenzo O, Chico J M, SanchezSerrano J J, et al Jasmonateinsensitive1 encodes a MYC transcription factor essentialto discriminate between different jasmonateregulated defenseresponses in Arabidopsis[J] Plant Cell, 2004, 16:1938
[72]Lu X, Zhang L, Zhang F, et al AaORA, a trichomespecific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea[J] New Phytol, 2013, 198(4):1191
[73]Shen Q, Yan T, Fu X, et al Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L[J]Sci Bull,2016, 61(1):18
[74]Yu Z X, Li J X, Yang C Q, et al The jasmonateresponsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L[J] Mol Plant, 2012, 5:353
[75]Tan H, Xiao L, Gao S, et alTrichome and Artemisinin Regulator 1 is required for trichome development and artemisinin biosynthesis in Artemisia annua[J] Mol Plant,2015, 8:1396
[76]Zhang F, Fu X, Lv Z, et alA basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua L[J] Mol Plant, 2015, 8:163, http://www.100md.com(谭何新 肖玲 周正张磊 陈万生)
[65]Zhang L, Jing F Y, Li F P, et al Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective antimalarial drug, by hairpinRNAmediated genesilencing[J] Biotechnol Appl Biochem,2009,52:199
[66]Cai Y, Jia J W, Crock J, et al AcDNA clone for βcaryophyllene synthase from Artemisia annua[J] Phytochemistry, 2002,61:523
[67]Chen J L, Fang H M, Ji Y P, et alArtemisinin biosynthesisenhancement in transgenic Artemisia annua plants by downregulation of the betacaryophyllene synthase gene[J] Planta Med, 2011,77:1759
[68]Han J, Wang H, Lundgren A, et al Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants[J] Phytochemistry, 2014, 102:89
[69]Ma D, Pu G, Lei C, et alIsolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha4,11diene synthase gene, a key gene of artemisinin biosynthesis[J] Plant Cell Physiol, 2009,50:2146
[70]Lu X, Jiang W, Zhang L, et al AaERF1 positively regulates the resistance to Botrytis cinerea in Artemisia annua[J] PLoS ONE, 2013, 8:e57657
[71]Lorenzo O, Chico J M, SanchezSerrano J J, et al Jasmonateinsensitive1 encodes a MYC transcription factor essentialto discriminate between different jasmonateregulated defenseresponses in Arabidopsis[J] Plant Cell, 2004, 16:1938
[72]Lu X, Zhang L, Zhang F, et al AaORA, a trichomespecific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea[J] New Phytol, 2013, 198(4):1191
[73]Shen Q, Yan T, Fu X, et al Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L[J]Sci Bull,2016, 61(1):18
[74]Yu Z X, Li J X, Yang C Q, et al The jasmonateresponsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L[J] Mol Plant, 2012, 5:353
[75]Tan H, Xiao L, Gao S, et alTrichome and Artemisinin Regulator 1 is required for trichome development and artemisinin biosynthesis in Artemisia annua[J] Mol Plant,2015, 8:1396
[76]Zhang F, Fu X, Lv Z, et alA basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua L[J] Mol Plant, 2015, 8:163, http://www.100md.com(谭何新 肖玲 周正张磊 陈万生)